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non substantial amendment submission, substantial and non substantial amendments, substantial amendment notification form, non substantial amendment eu, how to submit a non material amendment, formal and substantial amendment, substantial amendment vs formal amendment, non-substantial amendment clinical trial, substantial and nonsubstantial forms, non material amendment form, substantial protocol amendment definition, substantial amendment in idis, non-substantial, non material amendment application, one : si submission & amendment, non material amendment guidance, non material amendment application form, how to amend be form after submission